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Synthesis,characterization and biological evaluation of some 5-methylpyrazine carbohydrazide based hydrazones
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نویسنده
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ahmad m. ,hameed s. ,tahir m.n. ,israr m. ,anwar m. ,shah m.a. ,khan s.a. ,din g.
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منبع
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pakistan journal of pharmaceutical sciences - 2016 - دوره : 29 - شماره : 3 - صفحه:811 -817
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چکیده
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Pyrazine carbohydrazide based hydrazones were synthesized starting from 5-methylpyrazine-2-carboxylic acid. the acid was first converted to its methyl ester,which on further treatment with hydrazine hydrate transformed to carbohydrazide. the carbohydrazide was treated with differently substituted aromatic carbonyl compounds giving hydrazones. characterization of the synthesized compounds was carried out using modern spectroscopic techniques and unambiguously confirmed through x-ray crystallographic studies of compound 3d. the purity of the compounds was verified using elemental analysis. the target molecules were evaluated for urease inhibition,antioxidant and antimicrobial activity.
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کلیدواژه
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5-Methylpyrazine-2-carboxylic acid; Antimicrobial; Antioxidant; Hydrazones; Urease inhibition
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آدرس
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department of chemistry,quaid-i-azam university,islamabad,pakistan,medicinal botanic centre,pcsir laboratories complex,peshawar, Pakistan, department of chemistry,quaid-i-azam university,islamabad, Pakistan, department of physics,university of sargodha,sargodha, Pakistan, department of chemistry,kohat university of science and technology,kohat, Pakistan, department of chemistry,kohat university of science and technology,kohat, Pakistan, department of chemistry,hazara university,mansehra, Pakistan, department of chemistry,islamia college university,peshawar, Pakistan, institute of chemical sciences,university of peshawar,peshawar, Pakistan
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Authors
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