Evaluation of antimicrobial activities of Harmine,Harmaline,Nicotine and their complexes

Harmine,harmaline,nicotine and its various complexes synthesized have been characterized by physical,spectral and analytical methods and curtained for in-vitro antimicrobial activity against different bacterial and fungal species at two different concentrations i.e.100μ g/100μ l and 200μ g/100μ l dose level respectively. analysis showed that nicotine,zinc-nico,cd-nico,hg-nico,ni-nico,cu-nico,co-nico,harmine,and harmaline having conc. of 100ug/100ul had antibacterial activity on zero,5,4,10,zero,5,7,zero,zero strain of bacteria having an average of zero (sd=0.0000),15.2000 (sd=1.30384),18.2500 (sd=3.30404),20.2000 (sd=1.39841),zero (sd=0.0000),14.6000 (sd=0.89443),15.8571 (sd=1.34519),zero (sd=0.0000),zero (sd=0.0000) respectively. zinc (ii) chloride,cadmium (ii) iodide,mercury (ii) chloride,nickel (ii) chloride,copper (ii) chloride,cobalt (ii) chloride,mercury (ii) chloride,mercury (ii) harmine,mercury (ii) harmaline at 100ug/100ul is valid for 7,8,9,2,7,8,9,10,8 strains of bacteria with an average of 7.1429 (sd=1.06904),10.0000 (sd=5.01427),14.8889 (sd=6.00925),6.0000 (sd=0.0000),8.5714 (sd=4.27618),8.2500 (sd=0.88641),14.8889 (sd=6.00925),18.6000 (sd=2.45855),18.5000 (sd=1.85164) respectively. the above given compounds at the conc. of 200 μ g/100ul is valid for 10,9,10,8,8,10,10,10,10 strains of bacteria with an average of 8.1 (sd=1.66333),11.7778 (sd=5.28625),16.1000 (sd=6.36745),6.5000 (sd=0.92582),9.7500 (sd=4.43203),9.9000 (sd=2.76687),16.1000 (sd=6.36745),22.0000 (sd=2.44949),20.4000 (sd=2.75681) respectively. the above given compounds at conc. of 200 μ g/100ul showed antibacterial action on 3,8,8,10,3,9,8,zero,3 strains of bacteria with an average of 14(sd=0.000),16.8750 (sd=1.35620),18.2500 (sd=3.45378),22.7000 (sd=1.82878),14.3333 (sd=0.57735),16.7778 (sd=1.71594),zero (sd=0.000),12.0000 (sd=1.00000) respectively. hence according to the average value of the zone of inhibition,maximum antibacterial activity at 100-200ug/100ul is of hg-nico and mercury salt; mercury (ii) harmine having an average of 20.2000 (sd=1.39841)-22.7000 (sd=1.82878) and 18.6000 (sd=2.45855)-22.0000 (sd=2.44949). minimum antibacterial activity at 100-200ug/100ul is nicotine100,nicotine-nico100,harmine 100,harmaline 100,harmine 200 having zero average (sd=0.000).