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Protective potential of the methanol extract of Macrothelypteris oligophlebia rhizomes for chronic non-bacterial prostatitis in rats
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نویسنده
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han p. ,lai y.j. ,chen j. ,zhang x.n. ,chen j.l. ,yang x. ,xue p.p. ,ruan j.l.
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منبع
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pakistan journal of pharmaceutical sciences - 2016 - دوره : 29 - شماره : 4 - صفحه:1217 -1221
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چکیده
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The protective potential of the methanol extract of macrothelypteris oligophlebia rhizomes (mmo) for chronic non-bacterial prostatitis (cnp) in rats was investigated in the present study. carrageenan-induced cnp in rats was established. fifty rats were randomly divided into sham-operated (sham-ope) group,model group,positive control group (cernilton at a dose of 148mg/kg body weight) and two mmo-treated groups (mmo at doses of 600mg/kg and 300 mg/kg body weight). the anti-prostatitis effect was evaluated by prostate index,the levels of interleukin-10 (il-10),tumor necrosis factor alpha (tnf-á),cyclooxygenase-2 (cox-2) and prostaglandin e2 (pge2),and histopathological examination. after 20 days of administration,mmo could significantly decrease prostate index and the levels of il-10,tnf-α,cox-2 and pge2 in serum and could improve the prostate morphology in comparison with the model group. in summary,these results suggest that mmo possesses protective effects on prostate,which might be beneficial to further development for the treatment of cnp.
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کلیدواژه
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Chronic non-bacterial prostatitis; Macrothelypteris oligophleba; Methanol extract
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آدرس
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key laboratory of natural medicinal chemistry and resource evaluation,school of pharmacy,tongji medical college,huazhong university of science and technology,wuhan,china,department of pharmacy,central hospital of wuhan,wuhan, China, department of pharmacy,central hospital of wuhan,wuhan, China, key laboratory of natural medicinal chemistry and resource evaluation,school of pharmacy,tongji medical college,huazhong university of science and technology,wuhan, China, key laboratory of natural medicinal chemistry and resource evaluation,school of pharmacy,tongji medical college,huazhong university of science and technology,wuhan, China, key laboratory of natural medicinal chemistry and resource evaluation,school of pharmacy,tongji medical college,huazhong university of science and technology,wuhan, China, key laboratory of natural medicinal chemistry and resource evaluation,school of pharmacy,tongji medical college,huazhong university of science and technology,wuhan, China, key laboratory of natural medicinal chemistry and resource evaluation,school of pharmacy,tongji medical college,huazhong university of science and technology,wuhan, China, key laboratory of natural medicinal chemistry and resource evaluation,school of pharmacy,tongji medical college,huazhong university of science and technology,wuhan, China
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Authors
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