New ellagic acid derivative from the fruits of heat-tolerant plant Conocarpus lancifolius Engl. and their anti-inflammatory,cytotoxic,PPAR agonistic activities

Conocarpus lancifolius (combretaceae),is distributed in riyadh,saudi arabia. it is a heat-tolerant saudi medicinal plant,demonstrates prominent antidiabetic potential and the fruit extract fruits showed cytotoxicity against mrc-5 cancer cell line,as well as prominent antiprotozoal and antibacterial activities. the objective of this study is to isolate the compounds and evaluate the anti-inflammatory,cytotoxic,ppar agonistic and antioxidant activities of extracts and pure constituents from c. lancifolius. a new trimethoxyellagic acid derivative 1 and two compounds,kaempferol 3-o-rutinoside 2 and β-sitosterol glucoside 3 were isolated from the fruits of conocarpus lancifolius,a heat-tolerant plant. compound 2 showed strong dual activation for pparα and pparγ with 2.6 fold increment in pparα activity,while 2.2 fold increment in pparγ at 25μ/ml. this is first report on isolation and screening of different biological activities of extract and pure constituents from fruits of c. lancifolius.