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Synthesis,physicochemical characterization and pharmacological investigation of indolacin-5-fluorouracil-1-ylmethyl ester
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نویسنده
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wang j. ,zou m.-j. ,chen l. ,sheng y.-l. ,zhou x.-m. ,zhang x.-r.
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منبع
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pakistan journal of pharmaceutical sciences - 2016 - دوره : 29 - شماره : 6 - صفحه:1997 -2004
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چکیده
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The objective of this work is to synthesize indolacin-5-fluorouracil-1-ylmethyl ester and the structure was confirmed by means of uv,ir,1h-nmr,13c-nmr and mass spectrometry. the physicochemical parameters of melting point,solubility,apparent partition coefficient were investigated. s180 sarcoma,h22 hapatitic cancer and lewistransplanted mice were used to evaluate the anti-tumor activity of indolacini-5-fluorouracil-1-ylmethyl ester compared with 5-fluorouracil in vivo. anti-inflammatory and analgesic activities were evaluated in mice. the inhibitory ratio of indolacini- 5-fluorouracil-1-ylmethyl ester is comparative to that of 5-fluorouracil. this study indicates that 5- fluorouracil-1-ylmethyl ester may represent a new anticancer predrug of 5-fluorouracil to produce a combined effect of indolacin and 5-fluorouracil for cancer therapy.
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کلیدواژه
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5-Fluorouracil; Analgesic activity; Anti-inflammatory; Anti-tumor; Indolacini-5-fluorouracil-1-ylmethyl ester; LD50 values
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آدرس
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school of pharmacy,shenyang pharmaceutical university,103 wenhua road,shenyang, China, school of pharmacy,shenyang pharmaceutical university,103 wenhua road,shenyang, China, school of pharmacy,shenyang pharmaceutical university,103 wenhua road,shenyang, China, school of life science and biopharmaceutics,shenyang pharmaceutical university,wenhua road,shenyang, China, school of life science and biopharmaceutics,shenyang pharmaceutical university,wenhua road,shenyang, China, school of pharmacy,shenyang pharmaceutical university,103 wenhua road,shenyang, China
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Authors
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