Co-Treatment with imipramine averted haloperidol-instigated tardive dyskinesia: Association with serotonin in brain regions

Outcome of imipramine (imi) treatment was scrutinized on progression of haloperidol instigated tardive dyskinesia (td). 0.2 mg/kg/rat dosage of haloperidol provided orally to rats for 2 weeks enhanced vacuous chewing movements that escalated when the process proceeded for 5 weeks. following 2 weeks co-injection 5 mg/kg dosage of imi was diminished haloperidol-instigated vcms and fully averted following five weeks. the potency of 8-oh-dpatinstigated locomotor activity exhibited higher in saline+haloperidol treated rats while not observed in imi+ haloperidol treated rats. 8-oh-dpat-instigated low 5-hydroxytryptamine (5-ht; serotonin) metabolism was higher in saline+ haloperidol treated rats when compare to imi+ haloperidol treated rats in both regions of brain (striatum and midbrain). it is recommended that imi possibly competent in averting td,in cases receiving treatment to antipsychotics.