Synthesis and screening of some new N-alkyl/aralkyl-N-(3,4- methylenedioxybenzyl)-4-substituted benzenesulfonamides as potential antibacterial agents

The various p-substituted benzenesulfonyl chlorides (2a-e) were treated with (3,4-methylenedioxy) benzylamine (1) in the presence of aqueous na2co3 solution to synthesize n-(3,4-methylenedioxybenzyl)-4- substitutedbenzenesulfonamides (3a-e). the synthesized molecules were further converted into corresponding nethyl/ benzyl/4-flourobenzyl-n-(3,4-methylenedioxybenzyl)-4-substitutedbenzenesulfonamides (7a-e,8a-e,9a-e) on reaction with ethyl iodide (4),benzyl chloride (5) and 4-flourobenzyl chloride (6) in the presence of sodium hydride using n,n-dimethylformamide as solvent. the structure elucidation was processed through different spectral techniques including ir,1h-nmr and eims. the screening of the synthesized molecules against gram-bacterial strains,to evaluate antibacterial activity,showed them moderately good inhibitors as shown by their low mic values.