Synthesis,biological screening and molecular docking studies of some ethylated sulfonamides having 1,4-Benzodioxane moiety

The presented study comprises the synthesis of a new series of ethylated sulfonamides in which 1,4- benzodioxane moietyhas been incorporated. the reaction of 1,4-benzodioxane-6-amine (1) with ethane sulfonyl chloride (2) yielded n-(2,3-dihydrobenzo[1,4]dioxin-6-yl)ethanesulfonamide (3),which further on treatment with various alkyl/aralkyl halides,4a-r,in n,n□-dimethylformamide (dmf) and in the presence of lithium hydride (lih) acting as a weak base and catalyst;yielded derivativesofn-alkyl/aralkyl substituted n-(2,3-dihydrobenzo[1,4]dioxin-6- yl)ethanesulfonamides (5a-r). the characterization of these derivatives was carried out by different spectroscopic techniques like infra red,proton-nmr and mass spectrometry; then screened against various enzymes i.e. acetylcholinesterase,butyrylcholinesterase,lipoxygenase and α-glucosidase enzymes and five different bacterial strains. the synthesized compounds were found to be good inhibitors of lipoxygenase but moderate inhibitors of ache,bche and a-glucosidase; whereas compounds 3,5a,5f,5n and 5r were found good antibacterial compounds. the interaction between inhibitors and target enzymes (cholinestrases and lipoxygenase) was computationally observed which correlated with the experimental results.