Analgesic and anti-inflammatory activity of aqueous-methanolic extract of Aerva javanica

The present study was aimed to investigate the analgesic and anti-inflammatory activity of aqueous methanolic extract of aerva javanica. for measuring analgesic activity,writhing test,hot plate method and formalin test were performed and abdominal writhing was induced by intra-peritoneal injection of 0.2ml of 3% acetic acid. while in formalin test,pain was experimentally induced by injecting 25 μl of 2.5% formalin in left hind paw. in hot plate method,pain was induced thermally by keeping the animals on a hot plate with temperature of about 51°c. anti-inflammatory activity was assessed by carrageen an induced mice paw edema. the results showed that the extract had significant analgesic activity (p<0.05- p<0.001) and anti-inflammatory activity (p<0.01-p<0.001). therefore,it was concluded from this study that the extracts of aerva javanica may be used against pain and inflammation.