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Production of an antibiotic enterocin from a marine actinobacteria strain H1003 by metal-stress technique with enhanced enrichment using response surface methodology
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نویسنده
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hassan s.s. ,shah s.a.a. ,pan c. ,fu l. ,cao x. ,shi y. ,wu x. ,wang k. ,wu b.
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منبع
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pakistan journal of pharmaceutical sciences - 2017 - دوره : 30 - شماره : 1 - صفحه:313 -324
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چکیده
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Elicitation by chemical means including heavy metals is one of a new technique for drug discoveries. in this research,the effect of heavy metals on marine actinobacteria streptomyces sp. h-1003 for the production of enterocin,with a strong broad spectrum activity,along optimized fermented medium was firstly investigated. the optimum metal stress conditions consisted of culturing marine actinobacteria strain h-1003 with addition of cobalt ions at 2mm in optimized gause's medium having starch at 20mg/l for 10 days at 180 revolution/min. under these conditions,enterocin production was enhanced with a value of 5.33mg/l,which was totally absent at the normal culture of strain h-1003 and much higher than other tested metal-stress conditions. this work triumphantly announced a prodigious effect of heavy metals on marine actinobacteria with fringe benefits as a key tool of enterocin production.
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آدرس
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ocean college,zhejiang university,hangzhou, China, ocean college,zhejiang university,hangzhou, China, ocean college,zhejiang university,hangzhou, China, ocean college,zhejiang university,hangzhou, China, ocean college,zhejiang university,hangzhou, China, ocean college,zhejiang university,hangzhou, China, center of analysis and measurement,zhejiang university,hangzhou, China, department of applied chemistry,zhejiang gongshang university,hangzhou, China, ocean college,zhejiang university,hangzhou, China
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Authors
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