Evaluation of hypocholesterolemic activity of extracts of Bidens odorata and Brickellia eupatorioides

We sought to evaluate the hypolipidemic activity of extracts of bidens odorata and brickellia eupatorioides using a model of hyperlipidemia induced in rats by triton wr-1339 (300mg/kg intraperitoneally). the rats were divided into 5 groups of 3 rats each: normal control group,hyperlipidemic control group,hyperlipidemic with 20 mg/kg atorvastatin,hyperlipidemic with 300 mg/kg b. odorata extract,and hyperlipidemic with 300mg/kg b. eupatorioides extract,respectively. after 10 d of treatment by intragastric administration,the extract of b. odorata caused a significant decrease of serum total cholesterol and triglyceride levels without altering the liver enzymes aspartate transaminase and alanine aminotransferase. in addition,the extract had antioxidant potential as shown by the 2,2′-diphenyl-1-picrylhydrazyl technique. these findings indicate that b. odorata has potential as a hypolipidemic agent and might be beneficial in treatment of hyperlipidemia and atherosclerosis.