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Synthetic N-[(substitutedsulfamoyl)phenyl]acetamides as moderate chymotrypsin inhibitors
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نویسنده
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siddiqui s.z. ,zahid a. ,abbasi m.a. ,aziz-ur-rehman department of chemistry ,nasim f.-u.-h.
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منبع
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pakistan journal of pharmaceutical sciences - 2017 - دوره : 30 - شماره : 3 - صفحه:675 -681
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چکیده
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A facile method has been implemented for the synthesis of different n-substituted sulfamoylacetamides by reacting 4-acetamidobenzenesulfonyl chloride (1) with different alkyl/aralkyl/aryl amines (2a-q) in basic aqueous media under controlled ph to afford -[(substitutedsulfamoyl) phenyl]acetamides (3a-q) which were confirmed through spectral analysis like ft-ir,eims and 1h-nmr. moreover,the synthesized derivatives were screened against α-chymotrypsin. the enzyme inhibitory results revealed that most of the synthesized compounds were found to be moderate enzyme inhibitors.
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کلیدواژه
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4-Acetamidobenzenesulfonyl chloride; Alkyl/aralkyl/aryl amines; N-[(Substitutedsulfamoyl) phenyl] acetamides; Spectral characterization; α-Chymotrypsin and Enzyme inhibitory analysis
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آدرس
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department of chemistry,government college university,lahore, Pakistan, department of chemistry,government college university,lahore, Pakistan, department of chemistry,government college university,lahore, Pakistan, government college university,lahore, Pakistan, department of chemistry,islamia university of bhawalpur,bhawalpur, Pakistan
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Authors
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