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Evaluation of nephroprotective activity of Musa paradisiaca L. in gentamicin-induced nephrotoxicity
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نویسنده
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abbas k. ,rizwani g.h. ,zahid h. ,qadir m.i.
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منبع
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pakistan journal of pharmaceutical sciences - 2017 - دوره : 30 - شماره : 3 - صفحه:881 -890
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چکیده
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The objective of the study was to investigate the nephroprotective activity of methanolic extract of different morphological parts (bract,flower,trachea and tracheal fluid) of musa paradisiaca l. (family: musaceae) against gentamicin-induced nephrotoxicity in mice. gentamicin produced significant changes in biochemical (increased levels of blood urea nitrogen level,blood urea,and serum creatinine),and histological parameters in mice. treatment with methanolic extract of bract (100 and 250mg/kg,b.w) and flowering stalk (trachea) (250 and 500mg/kg,b.w) significantly prevented biochemical and histological changes produced by gentamicin toxicity. the extracts of m. paradisiaca(bract and flowering stalk) could contribute a lead to discovery of a new drug for the treatment of drug-induced nephrotoxicity.
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کلیدواژه
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Gentamicin; Histopathology; Musa paradisiaca L.; Renal function
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آدرس
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department of pharmacognosy,faculty of pharmacy,university of karachi,karachi,pakistan,department of pharmacognosy,faculty of pharmaceutical sciences,gc university faisalabad,faisalabad, Pakistan, department of pharmacognosy,faculty of pharmacy,university of karachi,karachi, Pakistan, department of pharmacognosy,faculty of pharmacy,university of karachi,karachi, Pakistan, institute of molecular biology and biotechnology,bahauddin zakariya university,multan, Pakistan
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Authors
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