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Evaluation of ED50 and 5α-reductase inhibitor activities of some thiopyrimidine,pyrane,pyrazoline and thiazolopyrimidine derivatives
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نویسنده
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amr a.e.-g.e. ,al-omar m.a. ,abdalla m.m.
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منبع
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pakistan journal of pharmaceutical sciences - 2017 - دوره : 30 - شماره : 3 - صفحه:833 -838
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چکیده
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In this work,twenty-one thiopyrimidine (1-21) candidates containing a pyrane,pyrazoline and thiazolopyrimidine ring screened for their ed50 and 5α-reductase inhibitors comparable to that of anastrozole as positive drug. some of the tested product showed moderate 5α-reductase inhibitors with lower toxicity. the detailed ed50 and 5α-reductase inhibitor activities of the synthesized compounds were studied.
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کلیدواژه
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5α-reductase inhibitors; Anstrazole; Citrazinic acid; Pyrimidinone; Thiazolopyrimidine
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آدرس
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pharmaceutical chemistry department,college of pharmacy,drug exploration and development chr. (dedc),king saud university,riyadh,saudi arabia,applied organic chemistry department,national research center,cairo,dokki, Egypt, pharmaceutical chemistry department,college of pharmacy,drug exploration and development chr. (dedc),king saud university,riyadh, Saudi Arabia, research unit,saco pharm. co.,6th october city, Egypt
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Authors
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