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Complexation of ibuprofen with water soluble p-sulfonatocalix [4]arene: A potential candidate for drug delivery application
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نویسنده
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khokhar t.s. ,memon s. ,panhwar q.k. ,memon f.n. ,memon a.a. ,samejo m.q. ,muneer s. ,tulu m.
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منبع
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pakistan journal of pharmaceutical sciences - 2017 - دوره : 30 - شماره : 3 - صفحه:783 -788
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چکیده
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Complexation of ibuprofen with water soluble p-sulfonatocalix[4]arene (3) was evaluated. both molecules exhibit a host and guest type complexation. ph,complex stoichiometry and binding constant were determined by uv-vis and ft-ir spectroscopy. the maximum complexation of 3 with ibuprofen occurs at ph 2. stability constant values (9.897) show that there is favorable complex formed due to vital role of p-sulfonatocalix[4]arene,while the thermodynamic parameters,i.e. δg,δh and δs have been found as -24.09 kj/mol,0.012 kj/mol and 0.12 kj/mol. k,respectively. the results show that 3 has efficiency to carry the drug at particular conditions and can be used for drug delivery as a carrier.
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کلیدواژه
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Drug delivery; Inclusion complex; P-sulfonatocalix[4]arene; Synthesis; Thermodynamic
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آدرس
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national centre of excellence in analytical chemistry,university of sindh,jamshoro, Pakistan, national centre of excellence in analytical chemistry,university of sindh,jamshoro, Pakistan, dr. m. a. kazi,institute of chemistry,university of sindh,jamshoro, Pakistan, national centre of excellence in analytical chemistry,university of sindh,jamshoro, Pakistan, national centre of excellence in analytical chemistry,university of sindh,jamshoro, Pakistan, dr. m. a. kazi,institute of chemistry,university of sindh,jamshoro, Pakistan, national centre of excellence in analytical chemistry,university of sindh,jamshoro, Pakistan, department of chemistry,faculty of arts and science,yildiz teknik university,davutpaşa campus,esenler,istanbul, Turkey
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Authors
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