Protective effects of Traditional Uighur medicine-seeds of Nigella glandulifera Freyn extracts against ccl4-induced acute hepatic injury in mice

To explore the protective effects of traditional uighur medicine seeds of nigella glandulifera freyn (snf) extracts against ccl4-induced acute hepatic injury in mice. hepatic injury mice models induced by intraperitoneal injection of 0.1% ccl4 olive oil were established. liver and spleen coefficient,serum alt and ast activities,sod,gsh-px activities and mda content in hepatic homogenate were measured and the hepatic histological changes were observed by optical microscope. serum activities of alt (p<0.01) and ast (p<0.05) in alcohol extraction group was decreased; activity of hepatic homogenate sod increased in alcohol extraction group and water extraction group significantly (p<0.05). content of mda was decreased in alcohol extraction group (p<0.01). water extracts of snf have obvious protective effects on hepatic injury induced by ccl4 in mice.