Synthesis,enzyme inhibition and molecular docking studies of 1- arylsulfonyl-4-Phenylpiperazine derivatives

Heterocyclic molecules have been frequently investigated to possess various biological activities during the last few decades. the present work elaborates the synthesis and enzymatic inhibition potentials of a series of sulfonamides. a series of 1-arylsulfonyl-4-phenylpiperazine (3a-n) geared up by the reaction of 1-phenylpiperazine (1) and different (un)substituted alkyl/arylsulfonyl chlorides (2a-n),under defined ph control using water as a reaction medium. the synthesized molecules were characterized by 1h-nmr,13c-nmr,ir and ei-ms spectral data. the enzyme inhibition study was carried on a-glucosidase,lipoxygenase (lox),acetyl cholinesterase (ache) and butyryl cholinesterase (bche) enzymes supported by docking simulation studies and the ic50 values rendered a few of the synthesized molecules as moderate inhibitors of these enzymes where,the compound 3e exhibited comparatively better potency against a-glucosidase enzyme. the synthesized compounds showed weak or no inhibition against lox,ache and bche enzymes.