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Synthesis,characterization and antinociceptive activities of novel 2-(2,4-dichlorophenyl)-4H-chromen-4-one
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نویسنده
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shoaib m. ,shah s.w.a. ,shah s. ,khan n. ,ahmed m.n.
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منبع
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pakistan journal of pharmaceutical sciences - 2017 - دوره : 30 - شماره : 6 - صفحه:2085 -2089
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چکیده
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A novel flavone derivative has been synthesized in good yield from ketone and aldehyde. the structure has been established by different spectroscopic techniques like 1h nmr,13c nmr,ir and elemental analysis. the compound was then screened for its acute toxicity and antinociceptive activity studies on animal model. the novel compound was safe upto a maximum dose of 500mg/kg body weight oral dose in mice and showed 65.92 and 82.18% pheriperal analgesic activity at 15 and 30mg/kg body weight doses. central antinociceptive activity of the compound was 53.13 and 64.44% at 15 and 30mg/kg body weight respectively.
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کلیدواژه
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Acute toxicity; Antinociceptive activity; Chalcone; Flavone; Flavonoids
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آدرس
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department of pharmacy,university of malakand,khyber pakhtunkhwa, Pakistan, department of pharmacy,university of malakand,khyber pakhtunkhwa, Pakistan, department of pharmacy,university of malakand,khyber pakhtunkhwa, Pakistan, department of pharmacy,university of malakand,khyber pakhtunkhwa, Pakistan, department of chemistry,university of azad jammu and kashmir,muzaffarabad, Pakistan
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Authors
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