Comparative efficacy of glycosaminoglycans extracted from chicken keel cartilage and fish on clinical signs of osteoarthritis and C-terminal telopeptides of type II collagen

Chondroitin sulphate (cs) and glucosamine sulphate (gs),building blocks of glycosaminoglycans are effectively used in the treatment of osteoarthritis in human beings. aim of the present study was to evaluate the efficacy of glycosaminoglycans,extracted from chicken keel cartilage and fish,on clinical signs of osteoarthritis and c-terminal telopeptides of type ii collagen;ctx-ii). the clinical signs scored from 28th day of induced osteoarthritis till 60th day of treatment were pain threshold,degree of lameness and swelling. serum concentrations of ctx-ii were determined s by enzyme linked immunosorbent assay elisa). highest mean pain score was recorded in oa un-treated followed by treated rats with gs,standard cs,extracted cs,extracted cs plus gs and standard cs plus gs. respective pattern was observed among treated and un-treated groups in elation to lameness. there was non-significant difference among swelling scores of induced un-treated and treated groups with extracted and standard cs. no clinical sign was observed in control group. highest serum concentration of ctx ii (pg/ml) was recorded in un-treated oa group (36.70±3.57),followed by groups treated with gs alone (6.12±0.13),standard cs (4.48±0.44),sample cs (4.40±0.50),gs plus sample cs (2.74±0.62),gs plus standard cs (2.62±0.66) and normal group (2.55±0.10). results of cs extracted from poultry were comparable in efficacy with standard cs from fish source (shark) alone and in combination with gs. © 2016,university of agriculture. all rights reserved.