Ameliorative effects of qurs-e-afsanteen on gentamicin induced hepatotoxicity and oxidative stress in rabbits

Qurs-e-afsanteen® has been reported to possess hepatoprotective potential,contains artemisia absinthium (afsanteen),valerianaofficinalis (sumbal-ut-tayyab),rheum emodi (ravendcheni),potassium nitrate and ammonium chloride. the present study was conducted to assess the protective effects of qurs-e-afsanteen against gentamicin-induced liver toxicity in rabbits. thirty rabbits were divided into five groups having six rabbits in each. group 1: normal control on routine diet; group 2: untreated control on gentasym® injection (gentamicin 80mg/kg i/p); group 3: treated control on gentasym® injection (gentamicin 80mg/kg i/p) + tablet silliver® (silymarin 200mg/kg orally); group 4: treated group i on gentasym® injection (gentamicin 80mg/kg i/p) + tablet qurs-e-afsanteen® (50mg/kg orally); group 5: treated group ii on gentasym® injection (gentamicin 80mg/kg i/p) + tablet qurs-e-afsanteen® (100mg/kg orally). qurs-e-afsanteen® showed high percentage of flavonoid and phenolic components upon phytochemical analysis. combination of qurs-e-afsanteen® with gentamicin restored the liver function parameters towards normal in a dose dependent manner. qurs-e-afsanteen® significantly increased hepatic total antioxidant capacity (tac),catalase (cat),superoxide dismutase (sod) and significantly decreased the total oxidant status (tos) and malondialdehyde (mda) levels. antimicrobial assay of qurs-e-afsanteen® exhibited significant antimicrobial activity and dna damage protection properties. histopathological analysis also supported the defensive nature of qurs-e-afsanteen® against gentamicin induced liver damage. © 2017,university of agriculture. all rights reserved.