Effectiveness and safety of pulsed radiofrequency treatment guided by computed tomography for refractory neuralgia of infraorbital nerve: A pilot study

Background: there is no truly optimal treatment to cure refractory neuralgia of the infraorbitalnerve. recently,nondestructive pulsed radiofrequency (prf) has become one of the most attractiveinterventional techniques for painful disorders. however,use of the technique for infraorbitalneuralgia has been seldom reported.objective: the purpose of this prospective study is to observe the effectiveness and safety of prftreatment for neuralgia of the infraorbital nerve.study design: prospective case series clinical outcome study.setting: university medical center,beijing,chinamethods: from january 2011 to november 2012,36 consecutive patients,following ineffectiveconservative therapy,underwent prf treatment and completed 2-year follow-up. numeric ratingscales (nrs),effective rate,additional carbamazepine dosage,and side effects were recorded atpostoperative day one,week one,week 2,month one,month 3,month 6,year one,and year2. patients were divided into effective group and ineffective group based on postoperative one-month total pain relief or more than 50% reduction in nrs and patients were satisfied with theeffect,and possible factors affecting efficacy were compared between the 2 groups.results: effective rates were 69%,69%,64%,50%,and 50% at postoperative month one,month 3,month 6,year one,and year 2,respectively. no serious side effects were observed,exceptthat 9 patients felt short-term (one -month duration) mild numbness. output voltage and tissueresistance in the effective group were significantly higher than the ineffective group (p < 0.01).intraoperative output voltage was negatively correlated with postoperative one -month nrs (r =-0.332,p < 0.05).limitations: the non-controlled and single-centered design of the study.conclusions: results demonstrated prf treatment under computed tomography (ct) guidancefor infraorbital neuralgia is safe,effective,and is expected to become an alternative for patientsexperiencing ineffective conservative therapy. increasing the output voltage of prf could be thechosen method to improve the efficacy. © 2015,american society of interventional pain physicians. all rights reserved.