natural disesquiterpenoids: an overview of their chemical structures, pharmacological activities, and biosynthetic pathways

Disesquiterpenoids are constructed by two sesquiterpenoid molecules, containing at least 30 carbons with various connection patterns, and numerous new skeletons have been constructed. the aim of this review is to comprehensively summarise the isolation, structural elucidation, chemical synthesis, possible biogenetic pathways, and important pharmacological activities of the natural disesquiterpenoids discovered between 2010 and 2020. modern analytical tools and synthetic means that have led to structural revisions as well as name corrections have also been included. here, 227 references and 470 compounds are summarized.