plant-derived endoperoxides: structure, occurrence, and bioactivity

Endoperoxides have received widespread interest as a research topic due to its ubiquitous structure, which confers interesting biological properties. it has been demonstrated that some endoperoxides possess antimalarial, cytotoxic, anti-inflammatory, neuroprotective, antiparasitic, antitumor, and antimicrobial activities. the present review summarizes the current knowledge about the structure, occurrence, peroxide detection methods, stability, biosynthesis, and biological activities of 206 endoperoxides isolated from 1911 to 2019, found in 115 plant species belonging to 36 different plant families. thirty-five new endoperoxides of different plant species have been reported since the last published review. in order to simplify our analysis, we classified plant endoperoxides considering the nature of the secondary metabolite.