|
|
|
|
The Brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids
|
|
|
|
|
|
|
|
نویسنده
|
Andrade Jean Paulo de ,Giordani Raquel B. ,Torras-Claveria Laura ,Pigni Natalia Belén ,Berkov Strahil ,Font-Bardia Mercè ,Calvet Teresa ,Konrath Eduardo ,Bueno Kelly ,Sachett Liana G. ,Dutilh Julie H. ,Borges Warley de Souza ,Viladomat Francesc ,Henriques Amelia T. ,Nair Jerald J. ,Zuanazzi José Angelo S. ,Bastida Jaume
|
|
منبع
|
phytochemistry reviews - 2016 - دوره : 15 - شماره : 1 - صفحه:147 -160
|
|
چکیده
|
Nine brazilian amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (ache) inhibitory activity via gc–ms and a modified ellman assay, respectively. a total of thirty-six alkaloids were identified in these plants, of which hippeastrum papilio and h. glaucescens exhibited the highest galanthamine content and the best ic50 values against ache. furthermore, hippeastrum vittatum and rhodophiala bifida also showed notable ache inhibitory effects. x-ray crystallographic data for four galanthamine-type compounds revealed significant differences in the orientation of the n-methyl group, which are shown to be related to ache inhibition.
|
|
کلیدواژه
|
Galanthamine ,GC–MS ,Hippeastrum ,Sanguinine ,X-ray crystallography
|
|
آدرس
|
Departament de Productes Naturals, Spain. Universidade Federal do Rio Grande do Sul, Brazil. Universidade do Espírito Santo, Departamento de Química, Brazil, Universidade Federal do Rio Grande do Sul, Brazil, Departament de Productes Naturals, Spain, Departament de Productes Naturals, Spain, Departament de Productes Naturals, Spain. AgroBioInstitute, Bulgaria, Centres Cientifics i Tecnologics, Spain, Cristal.lografia, Spain, Universidade Federal do Rio Grande do Sul, Brazil, Universidade Federal do Rio Grande do Sul, Brazil, Universidade Federal do Rio Grande do Sul, Brazil, Universidade de Campinas, Departamento de Botânica, Brazil, Universidade do Espírito Santo, Departamento de Química, Brazil, Departament de Productes Naturals, Spain, Universidade Federal do Rio Grande do Sul, Brazil, Departament de Productes Naturals, Spain, Universidade Federal do Rio Grande do Sul, Brazil, Departament de Productes Naturals, Spain
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|