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Health effects of phloretin: from chemistry to medicine
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نویسنده
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Behzad Sahar ,Sureda Antoni ,Barreca Davide ,Nabavi Seyed Fazel ,Rastrelli Luca ,Nabavi Seyed Mohammad
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منبع
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phytochemistry reviews - 2017 - دوره : 16 - شماره : 3 - صفحه:527 -533
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چکیده
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Dihydrochalcones are a class of secondary metabolites, whose demand in biological and pharmacological applications is rapidly growing. phloretin is one of the best known and abundant dihydrochalcone characterized by the presence of 2,6-dihydroxyacetophenone pharmacophore. it is a versatile molecule with anticancer, antiosteoclastogenic, antifungal, antiviral, anti-inflammatory, antibacterial and estrogenic activities and able to increase the fluidity of biological membranes and penetration of administered drugs. in this review we have performed a critical evaluation of available literature as far as phloretin beneficial effects and activation/block of intracellular signal cascade are of concern. in addition, we supply useful information on its chemical properties, sources and bioavailability.
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کلیدواژه
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Anticancer ,Dihydrochalcones ,Phenolic compound ,Phloretin
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آدرس
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Shahid Beheshti University of Medical Sciences, Department of Pharmacognosy, Iran, University of Balearic Islands, Grup de Nutrició Comunitària i Estrès Oxidatiu, Spain, University of Messina, Dipartimento di Scienze Chimiche, Italy, Baqiyatallah University of Medical Sciences, Iran, University of Salerno, Dipartimento di Farmacia, Italy, Baqiyatallah University of Medical Sciences, Iran
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Authors
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