Soybean isoflavonoids: role of GmMYB176 interactome and 14-3-3 proteins

Isoflavonoids are a group of plant natural compounds that are synthesized through a legume-specific branch of the phenylpropanoid pathway. they play numerous roles in plant–microbe interactions including inducers of nitrogen fixation and defense response in plants. consumption of a soy-rich diet containing isoflavonoids has been noted for several health and nutritional benefits in humans and animals. therefore, there are continuous efforts geared towards generating soybean cultivars with increased amount of isoflavonoids. however, isoflavonoid content is a complex polygenic trait that is influenced by multiple factors including genotype, environment, and the interaction between genotype and environment. in this review, we present the factors that regulate isoflavonoid content in soybean and discuss in detail the recent development on identifying the genetic factors that impact isoflavonoid synthesis and accumulation in soybean.