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NEOPTERIN, CELLULAR ADHESION MOLECULES AND MYELOPEROXIDASE IN PATIENTS WITH STABLE AND UNSTABLE ANGINA PECTORIS
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نویسنده
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Tretjakovs Peteris ,Jurka Antra ,Bormane Inga ,Mikelsone Indra ,Reihmane Dace ,Krievina Gita ,Marksa Iveta ,Elksne Karlina ,Verbovenko Jurijs ,Bahs Guntis
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منبع
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proceedings of the latvian academy of sciences section b natural exact and applied sciences - 2011 - دوره : 65 - شماره : 3&4 - صفحه:87 -93
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چکیده
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Recent data indicate that the serum level of neopterin, a marker of inflammation and immune modulator secreted by monocytes/macrophages, is elevated in patients with acute coronary syndrome (acs) and seems to be a prognostic marker for major cardiovascular events. soluble cellular adhesion molecules (scams) and myeloperoxidase (mpo) levels are also related to acs. the aim of the present study was to evaluate differences in serum levels of neopterin, scams and mpo between coronary artery disease and metabolic syndrome (cad-mets) patients with stable and unstable angina pectoris (sap, uap), and to clarify the relationships between neopterin and other biomarkers. the study included 60 patients with cad-mets who were classified into two groups, 30 patients with sap and 30 patients with uap. twenty healthy subjects were selected as controls (c). serum soluble vascular cell adhesion molecule-1 (svcam-1), intercellular cell adhesion molecule-1 (sicam-1), se-selectin and mpo levels were measured by luminex xmap technology, and serum neopterin concentrations were measured by radioimmunoassay. results: serum levels of neopterin, mpo, svcam-1, sicam-1, and se-selectin were significantly higher in patients with uap in comparison with the group of healthy controls (p < 0.05). patients with sap also had higher levels of these biomarkers than those in healthy controls (p < 0.05), except for se-selectin. the biomarker level did not differ between the two patient groups, except for mpo, which was significantly higher in the usp group (p < 0.05). neopterin was significantly correlated only with svcam-1 (p < 0.05). in conclusion, cad-met patients with sap had more apparent raised levels of serum sicam-1 and svcam-1, simultaneously with higher mpo and neopterin concentrations, in comparison to those in healthy subjects. however, uap is also associated with more substantial changes in mpo and significantly increased se-selectin levels. neopterin concentration was had a close correlation only with svcam-1
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کلیدواژه
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neopterin ,cellular adhesion molecules ,myeloperoxidase ,angina pectoris ,metabolic syndrome ,coronary artery disease
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آدرس
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Riga Stradins University, Chair of Human Physiology and Biochemistry, LATVIA. University of Latvia, Institute of Experimental and Clinical Medicine, LATVIA. Riga Eastern Clinical University Hospital, LATVIA, University of Latvia, Institute of Experimental and Clinical Medicine, LATVIA. Pauls Stradins Clinical University Hospital, LATVIA, University of Latvia, Institute of Experimental and Clinical Medicine, LATVIA, University of Latvia, Institute of Experimental and Clinical Medicine, LATVIA, University of Latvia, Institute of Experimental and Clinical Medicine, LATVIA, University of Latvia, Institute of Experimental and Clinical Medicine, LATVIA, Pauls Stradins Clinical University Hospital, LATVIA, Riga Stradins University, Chair of Human Physiology and Biochemistry, LATVIA, Riga Stradins University, Chair of Human Physiology and Biochemistry, LATVIA. Riga Eastern Clinical University Hospital, LATVIA, Riga Stradins University, Chair of Human Physiology and Biochemistry, LATVIA. Riga Eastern Clinical University Hospital, LATVIA
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Authors
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