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Molecular mechanisms of the physiological functions of the aryl hydrocarbon (dioxin) receptor,a multifunctional regulator that senses and responds to environmental stimuli
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نویسنده
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fujii-kuriyama y. ,kawajiri k.
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منبع
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proceedings of the japan academy series b-physical and biological sciences - 2010 - دوره : 86 - شماره : 1 - صفحه:40 -53
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چکیده
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The aryl hydrocarbon receptor (ahr) was originally identified as a ligandactivated transcription factor that is involved in the induction of xenobiotic-metabolizing cytochrome p4501a1 (cyp1a1). for several decades,ahr has been studied in relation to toxicology and pharmacology. with recent discoveries on novel ahr functions,ahr research has expanded into multiple aspects of physiology,such as reproduction,innate immunity and tumor suppression. in this review,we summarize and discuss recent progress in mechanistic and functional studies on ahr with particular emphasis on physiological processes. © 2010 the japan academy.
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کلیدواژه
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BHLH-PAS transcription factor; Environmental stimuli; Innate immunity; Reproduction; Tumor suppression; Ubiquitylation
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آدرس
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institute of molecular and cellular biosciences,university of tokyo,tokyo,japan,medical research institute,tokyo medical dental university,tokyo, Japan, research institute for clinical oncology,saitama cancer center,saitama, Japan
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Authors
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