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Genetic studies of rheumatoid arthritis
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نویسنده
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yamamoto k. ,okada y. ,suzuki a. ,kochi y.
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منبع
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proceedings of the japan academy series b-physical and biological sciences - 2015 - دوره : 91 - شماره : 8 - صفحه:410 -422
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چکیده
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Rheumatoid arthritis (ra) is a common autoimmune disease that results in significant morbidity. as with other complex disorders,genome-wide association studies (gwass) have greatly contributed to the current understanding of ra etiology. in this review,we describe the genetic configuration of ra as revealed primarily through gwass and their meta-analyses. in addition,we discuss the pathologic mechanisms of ra as suggested by the findings of genetic and functional studies of individual ra-associated genes,including hla-drb1,padi4,ptpn22,ccr6 and fcrl3,and the potential use of genetic information for ra treatment in clinical practice. © 2015 the japan academy.
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کلیدواژه
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Anti-citrullinated protein antibodies (ACPA); Autoimmune disease; Genomewide association study (GWAS); Human leucocyte antigen (HLA); Meta-analysis; Rheumatoid arthritis
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آدرس
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department of allergy and rheumatology,graduate school of medicine,the university of tokyo,tokyo,japan,laboratory for autoimmune diseases,center for integrative medical sciences,riken,yokohama, Japan, department of human genetics and disease diversity,graduate school of medical and dental sciences,tokyo medical and dental university,tokyo, Japan, laboratory for autoimmune diseases,center for integrative medical sciences,riken,yokohama, Japan, laboratory for autoimmune diseases,center for integrative medical sciences,riken,yokohama, Japan
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Authors
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