Treatment of rheumatoid arthritis with biological agents-as a typical and common immune-mediated inflammatory disease

Molecules involved in the disease process facilitated our understanding of pathogenesis of the disease with unknown etiology such as immune-mediated and inflammatory diseases. moreover,the targeted therapies against the proposed molecular targets by biological agents provide enormous benefits to the patients and societies. here,i will review recent progress of the biological treatment in the immune-inflammatory diseases by focusing on the rheumatoid arthritis,the disease characterized by persistent polyarthritis leading to joint destruction and disability with autoimmune features,as a role model. © 2017 the japan academy.