Does nebivolol influence serum concentrations of proinflammatory cytokines in hypertensive (SHR) and normotensive (WKY) rats?

A growing body of evidence suggests that some drugs used in cardiovascular diseases may modulate the level of proinflammatory cytokines. in the present study we examined whether nebivolol,a third generation β-adrenergic blocker,influences lipopolysaccharide (lps)-induced serum concentrations of tnf-α,il-1β,and il-6 in normotensive (wky) and spontaneously hypertensive rats (shr). nebivolol (5 mg/kg and 10 mg/kg) or vehicle were administered by gavage once a day for 21 days. the drug (5 mg/kg and 10 mg/kg) did not modify lps-stimulated serum concentrations of tnf-α,il-1β and il-6 in normotensive or hypertensive rats and did not affect the total cholesterol and hdlcholesterol level. nebivolol,at the dose of 10 mg/kg,significantly increased the triglyceride concentration in shr only. the results were accompanied by a statistically significant decrease in systolic,diastolic and mean blood pressure after 21 days of both of the drug doses. in hypertensive and normotensive rats,nebivolol had a hypotensive activity and neutral effect on lipid profile. in our in vivo model,the immunomodulating effect of the drug was not significant and probably did not depend on hemodynamic action. © 2010 by institute of pharmacology polish academy of sciences.