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Synthesis and cytotoxic activity of G3 PAMAM-NH2 dendrimer-modified digoxin and proscillaridin A conjugates in breast cancer cells
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نویسنده
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winnicka k. ,bielawski k. ,bielawska a.
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منبع
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pharmacological reports - 2010 - دوره : 62 - شماره : 2 - صفحه:414 -423
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چکیده
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The objective of this study was to determine the cytotoxicity,antiproliferative activity,and apoptosis induction activity of two modified glycosides - digoxin and proscillaridin a- conjugated to a generation 3 polyamidoamine dendrimer (g3 pamam-nh2) in human breast cancer cells. the results suggest that conjugation with the g3 pamam-nh2 dendrimer enhances the cytotoxicity of modified digoxin and proscillaridin aboth in mcf-7 and in mda-mb-231 breast cancer cells. additionally,the conjugate-induced apoptosis was significantly greater than apoptosis evoked by free modified digoxin and proscillaridin a. © 2010 by institute of pharmacology polish academy of sciences.
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کلیدواژه
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Anticancer drugs; Breast cancer; Digoxin; PAMAM dendrimer; Proscillaridin a
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آدرس
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department of pharmaceutical technology,medical university of biatystok,kilińskiego 1,pl 15-089 białystok, Poland, department of medicinal chemistry and drug technology,medical university of biatystok,kilińskiego 1,pl 15-089 białystok, Poland, department of medicinal chemistry and drug technology,medical university of biatystok,kilińskiego 1,pl 15-089 białystok, Poland
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Authors
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