Dose-response relationship analysis of pregabalin doses and their antinociceptive effects in hot-plate test in mice

The aim of this study was to determine the analgesic effects of pregabalin (a third-generation antiepileptic drug) using the acute thermal pain model (hot-plate test) in mice. linear regression analysis was used to evaluate a dose-response relationship between logarithms of pregabalin doses and their resultant maximum possible antinociceptive effects (mpae) using the hot-plate test in mice. from the linear equation of the dose-response relationship,doses of pregabalin that increased antinociceptive effects by 20%,30%,40%,and 50% were calculated and amounted to 9.33,24.80,65.93,and 175.26 mg/kg,respectively. in conclusion,pregabalin produces analgesic effects in a dose-dependent manner,as demonstrated using the hot-plate test in mice. copyright © 2010 by institute of pharmacology polish academy of sciences.