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Family-based study of brain-derived neurotrophic factor (BDNF) gene polymorphism in alcohol dependence
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نویسنده
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grzywacz a. ,samochowiec a. ,ciechanowicz a. ,samochowiec j.
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منبع
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pharmacological reports - 2010 - دوره : 62 - شماره : 5 - صفحه:938 -941
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چکیده
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Brain-derived neurotrophic factor (bdnf) belongs to a family of proteins related to the nerve growth factor family,which are responsible for the proliferation,survival and differentiation of neurons. bdnf is thought to be involved in the pathogenesis of bipolar disorder,schizophrenia,eating disorders and addiction. we hypothesize that a functionally relevant polymorphism of the bdnf gene promoter may be associated with the pathogenesis of alcohol dependence. we performed an association study of 141 families with alcohol dependence. one hundred and thirty-eight healthy control subjects were matched based on ethnicity and gender. an association between the bdnf val66met gene polymorphism and alcoholism was not found. copyright © 2010 by institute of pharmacology polish academy of sciences.
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کلیدواژه
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Alcohol dependence; BDNF; Family; Gene; TDT (transmission disequilibrium test); Trios
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آدرس
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department of psychiatry,pomeranian medical university,broniewskiego 26,pl 71-460 szczecin, Poland, department of psychiatry,pomeranian medical university,broniewskiego 26,pl 71-460 szczecin,poland,interdepartmental unit for pedagogical education,university of szczecin,szwolezerów 18a,pl 71-062 szczecin, Poland, department of laboratory diagnostics and molecular medicine,pomeranian medical university,powstańców wielkopolskich 72,pl 70-111 szczecin, Poland, department of psychiatry,pomeranian medical university,broniewskiego 26,pl 71-460 szczecin, Poland
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Authors
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