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Effects of morphine and methadone treatment on mRNA expression of Gα(i) subunits in rat brains
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نویسنده
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zelek-molik a. ,taracha e. ,nawrat d. ,bielawski a. ,lehner m. ,płaźnik a. ,nalepa i.
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منبع
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pharmacological reports - 2010 - دوره : 62 - شماره : 6 - صفحه:1197 -1203
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چکیده
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Methadone is clinically effective as substitution therapy in patients with opioid dependence. the diversity of methadone and morphine in their intracellular activity is postulated. we compared the effects of repeated daily treatment of sprague-dawley rats with morphine (10 mg/kg) and methadone (1 mg/kg) on the expression of the gα(i1-i3) mrnas in several rat brain areas using rt-qpcr. we found that both opioid receptor agonists decreased gα(i3) mrnain only the nucleus accumbens. although there was no difference in the influence of morphine and methadone on gα(i),our results indicate that among gα(i) subunits,the gα(i3) is specifically involved in the mechanism of action of both drugs. copyright © 2010 by institute of pharmacology polish academy of sciences.
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کلیدواژه
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G-protein α subunits; Methadone; Morphine; MRNA; Nucleus accumbens; Rat brain
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آدرس
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department of brain biochemistry,institute of pharmacology,polish academy of sciences,smȩtna 12,pl 31-343 kraków, Poland, department of neurochemistry,institute of psychiatry and neurology,sobieskiego 9,pl 02-957 warszawa, Poland, department of brain biochemistry,institute of pharmacology,polish academy of sciences,smȩtna 12,pl 31-343 kraków, Poland, department of brain biochemistry,institute of pharmacology,polish academy of sciences,smȩtna 12,pl 31-343 kraków, Poland, department of neurochemistry,institute of psychiatry and neurology,sobieskiego 9,pl 02-957 warszawa, Poland, department of neurochemistry,institute of psychiatry and neurology,sobieskiego 9,pl 02-957 warszawa, Poland, department of brain biochemistry,institute of pharmacology,polish academy of sciences,smȩtna 12,pl 31-343 kraków, Poland
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Authors
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