|
|
|
|
Effect of neuraminidase treatment on persistent epileptiform activity in the rat hippocampus
|
|
|
|
|
|
|
|
نویسنده
|
isaeva e. ,lushnikova i. ,savrasova a. ,skibo g. ,holmes g.l. ,isaev d.
|
|
منبع
|
pharmacological reports - 2011 - دوره : 63 - شماره : 3 - صفحه:840 -844
|
|
چکیده
|
Negatively charged sialic acid residues located close to pores of voltage-gated sodium channels substantially influence their gating properties. the in vitro low mg2+ seizure model is used to emulate difficult-to-treat status epilepticus. using this model on cultured hippocampal slices,we examined the effectiveness of desialylation in reducing persistent seizure-like activity. we show that desialylation in cultured hippocampal slices effectively suppresses seizure-like activity induced by low mg2+. these findings suggest that targeting negatively charged sialic acids may be an effective strategy to treat status epilepticus. copyright © 2011 by institute of pharmacology polish academy of sciences.
|
|
کلیدواژه
|
Hippocampus; Neuraminidase; Seizures; Surface charge
|
|
آدرس
|
department of general physiology of nervous system,bogomoletz institute of physiology,kiev,ukraine,state key laboratory for molecular and cellular biology,neuroscience center at dartmouth,dartmouth medical school,lebanon,nh,united states,department of neurology,neuroscience center at dartmouth,dartmouth medical school,lebanon,nh, United States, department of cytology,bogomoletz institute of physiology,bogomoletz st. 4,kiev,ukraine,state key laboratory for molecular and cellular biology,neuroscience center at dartmouth,dartmouth medical school,lebanon,nh, United States, department of general physiology of nervous system,bogomoletz institute of physiology,kiev,ukraine,state key laboratory for molecular and cellular biology,neuroscience center at dartmouth,dartmouth medical school,lebanon,nh, United States, department of cytology,bogomoletz institute of physiology,bogomoletz st. 4,kiev,ukraine,state key laboratory for molecular and cellular biology,neuroscience center at dartmouth,dartmouth medical school,lebanon,nh, United States, department of neurology,neuroscience center at dartmouth,dartmouth medical school,lebanon,nh, United States, department of general physiology of nervous system,bogomoletz institute of physiology,kiev,ukraine,state key laboratory for molecular and cellular biology,neuroscience center at dartmouth,dartmouth medical school,lebanon,nh,united states,department of neurology,neuroscience center at dartmouth,dartmouth medical school,lebanon,nh, United States
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|