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N-palmitoylethanolamide,an endocannabinoid,exhibits antidepressant effects in the forced swim test and the tail suspension test in mice
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نویسنده
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yu h.-l. ,deng x.-q. ,li y.-j. ,li y.-c. ,quan z.-s. ,sun x.-y.
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منبع
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pharmacological reports - 2011 - دوره : 63 - شماره : 3 - صفحه:834 -839
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چکیده
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The antidepressant-like effects of n-palmitoylethanolamide (pea),a putative endocannabinoid,was investigated in mice using the tail suspension test (tst) and the forced swimming test (fst). in tst,pea (10,20,and 40 mg/kg) produced a statistically significant reduction in immobility (50,32,and 34%,respectively,vs. the control group),whereas fluoxetine (20 mg/kg) reduced immobility by 38%. in fst,pea (5,10,and 20 mg/kg) produced a statistically significant reduction in immobility (15,21,and 36%,respectively),whereas fluoxetine (20 mg/kg) reduced immobility by 18%. moreover,pea (20 mg/kg) did not significantly change motor activity in a spontaneous behavioral test. in conclusion,pea (dose range of 5-40 mg/kg) administered orally reduced immobility in tst and fst,comparable to the antidepressant effect of fluoxetine,and had no effect on spontaneous activity in mice. copyright © 2011 by institute of pharmacology polish academy of sciences.
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کلیدواژه
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Forced swimming test; N-palmitoylethanolamide; Open-field test; Tail suspension test
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آدرس
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college of basic medicine,yanbian university,yanji,jilin,133000, China, college of pharmacy,yanbian university,yanji,jilin,133000, China, college of basic medicine,yanbian university,yanji,jilin,133000, China, college of basic medicine,yanbian university,yanji,jilin,133000, China, college of pharmacy,yanbian university,yanji,jilin,133000, China, college of animal science and technique,bayi agriculture university,daqing,heilongjiang,163319, China
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Authors
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