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N-phenylmaleimide derivatives as mimetic agents of the pro-inflammatory process: Myeloperoxidase activation
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نویسنده
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noldin v.f. ,vigil s.v.g. ,de liz r. ,cechinel-filho v. ,fröde t.s. ,creczynski-pasa t.b.
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منبع
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pharmacological reports - 2011 - دوره : 63 - شماره : 3 - صفحه:772 -780
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چکیده
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Myeloperoxidase (mpo) is an important enzyme that catalyzes the reaction between hydrogen peroxide and chloride to generate hypochlorous acid,which oxidizes a range of biomolecules and has been associated with inflammatory diseases. the synthetic compounds n-phenylmaleimide (nfm) and 4-methyl-n-phenylmaleimide (me-nfm) increased the mpo activity in vitro (of isolated enzyme and in isolated cells after animal treatment) and in vivo assays. mpo-induction may represent a good model system to investigate the molecular and cellular mechanisms of oxidative cell injury induced by activated neutrophils,and the interactions between damaging species involved in the respiratory burst. copyright © 2011 by institute of pharmacology polish academy of sciences.
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کلیدواژه
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Hypochlorous acid; Inflammation; Myeloperoxidase; N-phenylmaleimides; Neutrophils
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آدرس
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department of pharmaceutical sciences,federal university of santa catarina,88040-900 florianópolis - sc, Brazil, clinical analysis,center of science and health,federal university of santa catarina,88040-900 florianópolis - sc, Brazil, clinical analysis,center of science and health,federal university of santa catarina,88040-900 florianópolis - sc, Brazil, nucleous of chemico pharmaceutical investigations,itajaí valley university,88302-202 itajaí - sc, Brazil, clinical analysis,center of science and health,federal university of santa catarina,88040-900 florianópolis - sc, Brazil, department of pharmaceutical sciences,federal university of santa catarina,88040-900 florianópolis - sc, Brazil
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Authors
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