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Endocannabinoid system protects against cryptogenic seizures
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نویسنده
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van rijn c.m. ,perescis m.f.j. ,vinogradova l. ,van luijtelaar g.
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منبع
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pharmacological reports - 2011 - دوره : 63 - شماره : 1 - صفحه:165 -168
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چکیده
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Effects of the cannabinoid antagonist rimonabant on the eeg were investigated in healthy,non-epileptic rats. the drug was administered orally at 30 mg/kg/day for 3 weeks. the eeg was recorded continuously. in 3 out of 13 rats,limbic convulsive seizures,which were not related to the time of drug administration,were observed after 5-8 days. we hypothesize that an accumulation of micro-injuries in the brain is responsible for these spontaneous seizures. copyright © 2011 by institute of pharmacology polish academy of sciences.
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کلیدواژه
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Cannabis; Cryptogenic seizures; Endocannabinoid system; Epilepsy; Rimonabant
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آدرس
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donders institute for brain,cognition and behaviour,radboud university nijmegen,p.o.b. 9104,6500 he nijmegen, Netherlands, donders institute for brain,cognition and behaviour,radboud university nijmegen,p.o.b. 9104,6500 he nijmegen,netherlands,university for professional education has,den bosch, Netherlands, donders institute for brain,cognition and behaviour,radboud university nijmegen,p.o.b. 9104,6500 he nijmegen,netherlands,institute of higher nervous activity and neuropysiology,russian academy of sciences,moscow, Russian Federation, donders institute for brain,cognition and behaviour,radboud university nijmegen,p.o.b. 9104,6500 he nijmegen, Netherlands
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Authors
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