|
|
|
|
Dopaminergic drug-induced modulation of the expression of the dopamine transporter in peripheral blood lymphocytes in Parkinson's disease
|
|
|
|
|
|
|
|
نویسنده
|
fanciulli a. ,misasi r. ,campanelli d. ,buttarelli f.r. ,pontieri f.e.
|
|
منبع
|
pharmacological reports - 2011 - دوره : 63 - شماره : 4 - صفحه:1056 -1060
|
|
چکیده
|
The modulation of expression of the dopamine transporter by dopaminergic drugs was investigated by flow cytometry in peripheral blood lymphocytes from patients suffering parkinson's disease. an 8-week in vivo exposure to pramipexole (0.7 mg free base,3 times a day) or ropinirole (12 mg,once daily),but not levodopa/carbidopa (100/25 mg,3 times a day),significantly reduced the mean fluorescence intensity of the dopamine transporter in peripheral blood lymphocytes. these results demonstrate that levodopa differs from dopamine agonists in its regulation of dopamine transporter expression in peripheral blood lymphocytes. copyright © 2011 by institute of pharmacology polish academy of sciences.
|
|
کلیدواژه
|
Dopamine transporter; Levodopa; Parkinson's disease; Peripheral blood lymphocytes; Pramipexole; Ropinirole
|
|
آدرس
|
movement disorder unit,sant'andrea hospital,rome,italy,department of neurology and psychiatry,sapienza university,rome, Italy, department of experimental medicine,sapienza university,rome, Italy, department of neurology and psychiatry,sapienza university,rome, Italy, department of neurology and psychiatry,sapienza university,rome, Italy, movement disorder unit,sant'andrea hospital,rome,italy,department of neurology and psychiatry,sapienza university,rome, Italy
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|