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Neuropeptide FF receptor modulates potassium currents in a dorsal root ganglion cell line
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نویسنده
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mollereau c. ,roumy m. ,zajac j.-m.
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منبع
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pharmacological reports - 2011 - دوره : 63 - شماره : 4 - صفحه:1061 -1065
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چکیده
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This study investigated the presence of neuropeptide ff (npff) receptors on f-11 cells,a hybridoma derived from rat dorsal root ganglia (drg) and mouse neuroblastoma. binding experiments revealed a low density (4 fmol/mg) of high affinity (0.5 nm) [3h]-eyf binding sites in these cells. the whole-cell planar patch-clamp technique showed that dnpa,a selective npff 2 agonist,increased the voltage-dependent potassium outward currents (about 30 pa/pf) by 21%; this reversible effect on sustained delayed potassium currents is blocked by tetraethylammonium. the similar effects of npff and opioid agonists on k+ currents in this cell line may explain their similar antinociceptive actions at the spinal level. copyright © 2011 by institute of pharmacology polish academy of sciences.
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کلیدواژه
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Neuroblastoma F-11 cell; Neuropeptide FF; Opioid; Receptor
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آدرس
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institut de pharmacologie et de biologie structurale,cnrs/université de toulouse,umr 5089,205 route de narbonne,31077 toulouse cedex, France, institut de pharmacologie et de biologie structurale,cnrs/université de toulouse,umr 5089,205 route de narbonne,31077 toulouse cedex, France, institut de pharmacologie et de biologie structurale,cnrs/université de toulouse,umr 5089,205 route de narbonne,31077 toulouse cedex, France
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Authors
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