Differential effects of glycine on the anticonvulsant activity of D-cycloserine and L-701,324 in mice

The anticonvulsant effects of d-cycloserine,which is a partial agonist of the glycine/n-methyl-d-aspartate (nmda) receptor,and l-701,324,which is a selective and potent antagonist that acts at the glycine site,were studied in electroshock-induced seizures in mice. glycine,which is a natural full agonist that acts at the glycine site,enhanced the seizure threshold-increasing effect of d-cycloserine. l-701,324 produced a marked increase in the seizure threshold,which was significantly reversed by the administration of glycine. these results suggest that indirect glycine/nmda antagonistic mechanisms may be responsible for the anticonvulsant action of d-cycloserine. copyright © 2011 by institute od pharmacology polish academy of sciences.