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Effects of norepinephrine on the electrical activities of pain-related neurons in the rat nucleus accumbens
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نویسنده
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zhang d. ,yang d.-x. ,yang c.-x. ,zhang g.-w. ,gao h.-r. ,zhai y. ,jiao r.-s. ,zhang y. ,zhang h. ,liang y. ,xu m.-y.
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منبع
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pharmacological reports - 2011 - دوره : 63 - شماره : 2 - صفحه:417 -422
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چکیده
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This study examined the effects of norepinephrine (ne) and phentolamine on the electrical activities of pain-excited neurons (pens) and pain-inhibited neurons (pins) in the nucleus accumbens (nac) of wistar rats. trains of electric pulses applied to the right sciatic nerve were used to provide noxious stimulation,and the discharges of pens and pins were recorded using a glass microelectrode. our results revealed that in response to noxious stimulation,ne decreases the evoked discharge frequency of pens and increases the evoked discharge frequency of pins in the nac of healthy rats,whereas phentolamine produced opposite responses. these results demonstrate that ne is involved in the modulation of nociceptive information transmission in the nac. copyright © by institute of pharmacology polish academy of sciences.
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کلیدواژه
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Electrical activity; Norepinephrine; Nucleus accumbens; Pain-related neuron; Phentolamine
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آدرس
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laboratory of neural electrophysiology,department of physiology,harbin medical university,harbin,heilongjiang,150081, China, second affiliated hospital,harbin medical university,harbin,heilongjiang,150081, China, second affiliated hospital,harbin medical university,harbin,heilongjiang,150081, China, laboratory of neural electrophysiology,department of physiology,harbin medical university,harbin,heilongjiang,150081,china,third affiliated hospital,harbin medical university,194 xuefu road,nangang district,harbin,heilongjiang,150081, China, laboratory of neural electrophysiology,department of physiology,harbin medical university,harbin,heilongjiang,150081, China, laboratory of neural electrophysiology,department of physiology,harbin medical university,harbin,heilongjiang,150081, China, laboratory of neural electrophysiology,department of physiology,harbin medical university,harbin,heilongjiang,150081, China, laboratory of neural electrophysiology,department of physiology,harbin medical university,harbin,heilongjiang,150081, China, laboratory of neural electrophysiology,department of physiology,harbin medical university,harbin,heilongjiang,150081, China, laboratory of neural electrophysiology,department of physiology,harbin medical university,harbin,heilongjiang,150081, China, laboratory of neural electrophysiology,department of physiology,harbin medical university,harbin,heilongjiang,150081, China
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Authors
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