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Antiarrhythmic and hypotensive activities of 1-[2-hydroxy-3-(4-phenyl-1- piperazinyl)propyl]-pyrrolidin-2-one (MG-1(R,S)) and its enantiomers
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نویسنده
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sapa j. ,filipek b. ,nowiński l.
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منبع
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pharmacological reports - 2011 - دوره : 63 - شماره : 2 - صفحه:455 -463
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چکیده
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The compound mg-1(r,s),(1-[2-hydroxy-3(4-phenyl-1-piperazinyl)propyl]- pyrrolidin-2-one,and its enantiomers were tested for electrocardiographic,antiarrhythmic and hypotensive activities. the racemic mixture (mg-1(r,s)) and its s-enantiomer significantly decreased systolic and diastolic blood pressure and possessed antiarrhythmic activity. the s-enantiomer displayed the greatest effect. the r-enantiomer did not show antiarrhythmic or hypotensive activity. the results suggest that the antiarrhythmic and hypotensive effects of these compounds are related to their adrenolytic properties. copyright © 2011 by institute of pharmacology polish academy of sciences.
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کلیدواژه
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Antiarrhythmic; Enantiomer; Phenylpiperazine-pyrrolidine-2-one; α-adrenoceptor blocking activity
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آدرس
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department of pharmacodynamics,medical college,jagiellonian university,medyczna 9,pl 30-688 kraków, Poland, department of pharmacodynamics,medical college,jagiellonian university,medyczna 9,pl 30-688 kraków, Poland, department of pharmacodynamics,medical college,jagiellonian university,medyczna 9,pl 30-688 kraków, Poland
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Authors
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