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Kynurenic acid and kynurenine aminotransferases in retinal aging and neurodegeneration
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نویسنده
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rejdak r. ,junemann a. ,grieb p. ,thaler s. ,schuettauf f. ,choraģiewicz t. ,zarnowski t. ,turski w.a. ,zrenner e.
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منبع
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pharmacological reports - 2011 - دوره : 63 - شماره : 6 - صفحه:1324 -1334
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چکیده
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The kynurenine aminotransferases (kats) kat i and kat ii are pivotal to the synthesis of kynurenic acid (kyna),the only known endogenous glutamate receptor antagonist and neuroprotectant. kat i and ii have been found in avian,rodent,and human retina. expression of kat i in müller cell endfeet and kat ii in retinal ganglion cells has been documented. developmental changes in kat expression and kyna concentration in the avian and rodent retina have also been found. studies of retinal neurodegeneration have shown alterations in kyna synthesis in the retina in response to retinal ganglion cell loss. in dba/2j mice,a model of ocular hypertension,an age-dependent decrease of retinal kyna and kats was found. in the corpora amylacea in the human retina intensive kat i and ii immunoreactivity was demonstrated. in summary,these findings point to the potential involvement of kyna in the mechanisms of retinal aging and neurodegeneration. copyright © 2011 by institute of pharmacology polish academy of sciences.
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کلیدواژه
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Kynurenic acid; Kynurenine aminotransferase; Neurodegeneration
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آدرس
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centre for ophthalmology,university of tübingen,roentgenweg 11,d-72076 tübingen,germany,department of ophthalmology,medical university,chmielna 1,pl 20-079 lublin,poland,medical research centre,polish academy of science,pawińskiego 5,pl 02-106 warszawa, Poland, department of ophthalmology,friedrich-alexander university erlangen-nurnberg,schwabachanlage 6,91054 erlangen, Germany, medical research centre,polish academy of science,pawińskiego 5,pl 02-106 warszawa, Poland, centre for ophthalmology,university of tübingen,roentgenweg 11,d-72076 tübingen, Germany, centre for ophthalmology,university of tübingen,roentgenweg 11,d-72076 tübingen, Germany, department of ophthalmology,medical university,chmielna 1,pl 20-079 lublin, Poland, department of ophthalmology,medical university,chmielna 1,pl 20-079 lublin, Poland, department of experimental and clinical pharmacology,medical university,jaczewskiego 8,pl 20-090 lublin,poland,department of toxicology,institute of agricultural medicine,jaczewskiego 2,pl 20-090 lublin, Poland, centre for ophthalmology,university of tübingen,roentgenweg 11,d-72076 tübingen, Germany
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Authors
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