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Kynurenic acid: A new effector of valproate action?
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نویسنده
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maciejak p. ,szyndler j. ,turzyńska d. ,sobolewska a. ,płaźnik a.
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منبع
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pharmacological reports - 2011 - دوره : 63 - شماره : 6 - صفحه:1569 -1573
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چکیده
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We investigated the changes in hippocampal kynurenic acid (kyna) concentrations and the amino acids involved in neuronal activity regulation following valproate (vpa) administration (400 mg/kg ip) in pentylenetetrazole- kindled rats (in vivo).we found a remarkably long-lasting increase in kynalevels following vpaadministration,and this effect correlated with a rise in gabalevels. no changes in the concentration of other analyzed amino acids were present. it is likely that the antiepileptic and neuroprotective properties of vpa may also be a consequence of an increase in the hippocampal kyna concentration. copyright © 2011 by institute of pharmacology polish academy of sciences.
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کلیدواژه
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Epilepsy; GABA; Kynurenic acid; Microdialysis; Neuroprotection; PTZ-kindling; Steady state; Valproate
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آدرس
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department of neurochemistry,institute of psychiatry and neurology,sobieskiego 9,pl 02-957 warszawa,poland,department of experimental and clinical pharmacology,medical university of warsaw,krakowskie przedmieście 26/28,pl 00-927 warszawa, Poland, department of experimental and clinical pharmacology,medical university of warsaw,krakowskie przedmieście 26/28,pl 00-927 warszawa, Poland, department of neurochemistry,institute of psychiatry and neurology,sobieskiego 9,pl 02-957 warszawa, Poland, department of neurochemistry,institute of psychiatry and neurology,sobieskiego 9,pl 02-957 warszawa, Poland, department of neurochemistry,institute of psychiatry and neurology,sobieskiego 9,pl 02-957 warszawa,poland,department of experimental and clinical pharmacology,medical university of warsaw,krakowskie przedmieście 26/28,pl 00-927 warszawa, Poland
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Authors
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