|
|
|
|
Is rapid effect of thyroxine on GABAergic IPSCs purely postsynaptic?
|
|
|
|
|
|
|
|
نویسنده
|
storozhuk m. ,ivanova s. ,nikolaenko l. ,krishtal o.
|
|
منبع
|
pharmacological reports - 2012 - دوره : 64 - شماره : 6 - صفحه:1573 -1577
|
|
چکیده
|
Background: thyroid hormones (ths) are well known for their genomic effects but recently several studies revealed their actions as rapid modulators of membrane receptors. in particular,fast thyroxine effect on gabaa receptors have been reported. we addressed question whether presynaptic mechanisms can be also involved in modulation of gabaergic transmission by thyroxine. methods: using patch-clamp technique we examined fast effects of thyroxine (2 ìm) on evoked gabaergic postsynaptic currents. results: we found that in addition to the inhibitory effect on ipsc amplitude,thyroxine changed ipsc coefficient of variation (cv). conclusion: this result suggests involvement of a presynaptic mechanism in thyroxine effect on gabaergic transmission. copyright © 2012 by institute of pharmacology.
|
|
کلیدواژه
|
GABAergic; Hippocampal neurons; Synaptic plasticity; Thyroxine
|
|
آدرس
|
a.a. bogomoletz institute of physiology,01024 kiev,ukraine,state key laboratory of molecular and cellular biology,bogomoletz 4,01024 kiev, Ukraine, international center of molecular physiology,01024 kiev,ukraine,a.a. bogomoletz institute of physiology,01024 kiev,ukraine,state key laboratory of molecular and cellular biology,bogomoletz 4,01024 kiev, Ukraine, a.a. bogomoletz institute of physiology,01024 kiev, Ukraine, international center of molecular physiology,01024 kiev,ukraine,a.a. bogomoletz institute of physiology,01024 kiev,ukraine,state key laboratory of molecular and cellular biology,bogomoletz 4,01024 kiev, Ukraine
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|