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The multidrug transporter P-glycoprotein in pharmacoresistance to antiepileptic drugs
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نویسنده
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stȩpień k.m. ,tomaszewski m. ,tomaszewska j. ,czuczwar s.j.
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منبع
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pharmacological reports - 2012 - دوره : 64 - شماره : 5 - صفحه:1011 -1019
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چکیده
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This review provides an overview of the knowledge on p-glycoprotein (p-gp) and its role as a membrane transporter in drug resistance in epilepsy and drug interactions. overexpression of p-gp,encoded by the abcb1 gene,is involved in resistance to antiepileptic drugs (aeds),limits gastrointestinal absorption and brain access of aeds. although several association studies on abcb1 gene with drug disposition and disease susceptibility are completed to date,the data remain unclear and incongruous. although the literature describes other multidrug resistance transporters,p-gp is the main extensively studied drug efflux transporter in epilepsy. copyright © 2012 by institute of pharmacology polish academy of sciences.
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کلیدواژه
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Antiepileptic drugs; Multidrug transporter; P-glycoprotein; Pharmacoresistance
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آدرس
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clinical biochemistry and metabolic medicine department,central manchester foundation trust,oxford road,m13 9wl manchester, United Kingdom, department of cardiology,medical university of lublin,pl 20-954 lublin,poland,department of internal medicine in nursing,medical university of lublin,jaczewskiego 8,pl 20-954 lublin, Poland, department of internal medicine in nursing,medical university of lublin,jaczewskiego 8,pl 20-954 lublin,poland,department of vitreoretinal surgery,medical university of lublin,chmielna 1,pl 20-079 lublin, Poland, department of pathophysiology,medical university of lublin,jaczewskiego 8,pl,20-090 lublin,poland,department of physiopathology,institute of agricultural medicine,jaczewskiego 2,pl 20-950 lublin, Poland
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Authors
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