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Serotonin 2A receptor gene (HTR2A) polymorphism in alcohol-dependent patients
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نویسنده
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wrzosek m. ,jakubczyk a. ,wrzosek m. ,matsumoto h. ,łukaszkiewicz j. ,brower k.j. ,wojnar m.
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منبع
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pharmacological reports - 2012 - دوره : 64 - شماره : 2 - صفحه:449 -453
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چکیده
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Background: the serotonergic (5-ht) dysfunction has been frequently described in subjects with alcohol dependence (ad). in the present study,a potential relationship between t102c polymorphism in the 5-ht receptor subtype 2a gene (htr2a) and alcohol dependence was examined. methods: genotypes were analyzed in 150 ad patients diagnosed with dsm-iv criteria and in 80 healthy controls. results: the genetic analysis showed that the frequency of 102c allele and c102c genotype in ad subjects was significantly higher than in controls. moreover,ad patients homozygous for c allele had significantly lower age at onset of alcohol problems than subjects having at least one t allele. conclusion: the results suggest a potential role of the t102c htr2a polymorphism in development of alcohol dependence. copyright © 2012 by institute of pharmacology polish academy of sciences.
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کلیدواژه
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Alcohol dependence; Genetic polymorphism; HTR2A
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آدرس
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department of pharmacogenomics,medical university of warsaw,pl 02-091 warszawa, Poland, department of psychiatry,medical university of warsaw,pl 02-091 warszawa, Poland, department of internal medicine and diabetology,medical university of warsaw,pl 02-091 warszawa, Poland, department of psychiatry,medical university of warsaw,pl 02-091 warszawa, Poland, department of biochemistry and clinical chemistry,medical university of warsaw,zwirki i wigury 61,pl 02-091 warszawa, Poland, department of psychiatry,university of michigan,4250 plymouth rd.,ann arbor,mi 48109, United States, department of psychiatry,medical university of warsaw,pl 02-091 warszawa,poland,department of psychiatry,university of michigan,4250 plymouth rd.,ann arbor,mi 48109, United States
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Authors
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