Strontium ranelate treatment improves oxidative damage in osteoporotic rat model

Background: osteoporosis is the most common skeletal disorder and is considered a risk of fracture. most medication used for the treatment of osteoporosis is antiresorptive; however,strontium ranelate (sr) therapy in postmenopausal women has shown a double effect on resorption and bone formation. in this study,the effect of sr on status of the oxidative stress and antioxidant defence system was investigated. methods: twenty-one adult albino female wistar rats were used. the animals were randomly assigned into three groups,control (sham operated rats,received saline),ovx (ovariectomized rats),ovx + sr (4 months later ovariectomy,strontium ranelate treatment was begun and continued for 120 days) each containing 7 animals. strontium ranelate (500 mg/kg/day) and placebo (saline) were administered via oral gavage. at the end of the treatment,liver and kidney of rats were removed and malondialdehyde (mda) level,superoxide dismutase (sod),glutathione peroxidase (gsh-px) and catalase (cat) activities were determined by biochemical analysis methods. results: in liver,mda levels were significantly higher in the ovx and ovx + sr groups than the control group. gsh-px activity decreased in ovx group and increased in ovx + sr group compared with values of control group. cat activity was increased in the ovx + sr group when compared to control group. in kidney,mda level was increased in ovx group. sod activity was decreased in the ovx + sr group. gsh-px activity decreased in ovx group and increased in ovx + sr group compared with control group. cat activity increased in the ovx + sr group when compared to control. conclusion: according to our results,sr has preventive effect on oxidative damage in ovariectomized rats. copyright © 2012 by institute of pharmacology polish academy of sciences.